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which may explain the constitutive localization at the cell periphery in puncta under basal ER Ca 2+ levels that is specific to ceSTIMs. We have also been studying C. elegans ORAI (ceORAI) as well as human ORAI isoforms and succeeded in expression and purification of the multimeric functional form of the ceORAI channel. We plan to perform further structural and functional studies on ceSTIM and ceORAI in order to elucidate common and diverged mechanisms associated with SOCE between C. elegans and mammals. We believe that our studies of ancestral IP3R
SaveTotal Grants
1
Total Amount
$0
Provinces Served
1
Top Recipients by Funding Amount
| # | Recipient | Grants | Total Amount |
|---|---|---|---|
| 1 | C. elegans. In this proposal we will study the primitive homologues of human stromal interacting proteins (STIMs) and ORAI Ca2+ channels | 1 | $0 |
Geographic Distribution by Province
| Province / Territory | Grants | Total Amount | Share |
|---|---|---|---|
| 2 & 3) in mammals. However | 1 | $0 | 0% |
Recent Grants
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C. elegans. In this proposal we will study the primitive homologues of human stromal interacting proteins (STIMs) and ORAI Ca2+ channels
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