Unity Health Toronto|Unity Health Toronto

Purpose

Vision loss due to Space Associated Neuro-Ocular Syndrome (SANS) is observed in many astronauts, is poorly understood, and remains one of the most feared hazards of space flight. The loss of gravity causes shift of fluids, including blood to the upper body, and these disturbances around the eye, especially in the choroid, the most vascularized tissue in the body, may be an important piece of the puzzle. Novel non-invasive eye imaging techniques will be used to examine blood vessel changes in the choroid for the first time in a model of SANS. Discovering biomarkers of excess and persistent blood and fluid entry into the eye will be an important step toward understanding and predicting SANS and preventing vision loss from SANS in astronauts.