Université Laval

Purpose

In order to provide effective antibiotics, it is critical that Canada find mechanisms to deal with antibiotic microbial resistance (AMR). In the Project, the goal is to develop a novel phage-based antibiotic delivery system as an alternative to antimicrobials. The Project will include collaborative research between Université Laval and NRC to use the developed phage collection and in vitro phage assays to explore targeted delivery. The Project will perform genome engineering of lead phages to modulate virulence, optimize host range of clinical isolates and minimize resistance development. These efforts are expected to help evaluate the functions of genes/proteins from selected Acinetobacter baumannii lytic phages, for potential therapy as alternatives to antibiotics.