48Hour Discovery Inc.

Purpose

The proposed project will develop a new high-value service client; this involves establishing “synthesis and validation of hits” at 48Hour Discovery INC (48HD). The deliverable from achieving this objective is an extremely valuable investigational new drug (IND) enabling discovery pipeline. The pipeline consists of I) genetically-encoded library technology (BiGEL2) for the discovery of bicyclic ligands for cell-based targets, II) high throughput synthesis of selected discovered ligand, III) measurement of binding and specificity profile and IV) permeability assays. These scaffolds are stable and resilient to simulated gastrointestinal conditions and thus, the discovery platform will provide potentially oral and bioavailable therapeutics.